Publications

Gover, G.J., Kelly, J., Moore, G., Jacoby, H., Karmali, R.A., Gorman, G.S. Comparative Pharmacokinetic profile of carboxyamidotriazole and carboxyamidotriazole orotate. Cancer Therapy, 2007, 5: 437-442.

Karmali R., Maxuitenko, Y., Gorman, G., Page, J.G. Carboxyamidotriazole Orotate and Cytotoxic Chemotherapy have a synergistic Effect on Tumor Inhibition in Glioblastoma and Colon Xenograft Mouse Models. Cancer Therapy. 2011;8:71-80. Epub 20 December 2011.

Corrado, C., Flugy, A.M., Taverna, S., Raimondo, S., Guggino, G., Karmali, R.A., et al. (2012) Carboxyamidotriazoleorotate Inhibits the growth of imatinib-resistant chronic myeloid leukaemia cells and modulates exosomes-stimulated angiogenesis. PLoS One, 7(8).

Karmali, R.A., Maxuitenko, Y., Gorman, G., Qu, Z. Combinatorial treatment with Carmoxyamidotriazole Orotate and Temozolomide in sc-Implanted human LOX IMVI melanoma xenografts. J. Solid Tumors, 2012, 2: 1-16.

Karmali, R.A., Maxuitenko, Y., Gorman, G. Treatment with Paclitaxel Orotate and Carboxyamidotriazole Orotate in SC-Implanted OVCAR-5 Human Ovarian Tumor Xenografts. J. Cancer Therapy, 2013, 4: 857-871.

Taylor M.H., Sandler A., Urba W.J., Omuro A.M.P., Gorman G.S., Karmali R.A.. Effect of carboxyamidotriazole orotate, a modulator or calcium-dependent signaling pathways, on advanced solid tumors. JCT. 2015; 6:322-333.

Oruro A., Karmali, R.A., Pentsova, E., Multicenter Phase 1B Trial of Carboxyamidotriazole Rotate and Temozolomide for Recurrent and Newly Diagnosed Glioblastoma and Other Anapestic Glioblastoma. J. Clin. Once. (2018) In Press Data Supplement; JCO. 2017; 76:9992.