Tactical’s CTO is an important candidate for cancer therapy because CAI has been shown to
Inhibit angiogenesis, inhibit intracellular calcium influx, inhibit signal transduction and ultimately down-regulation of the production of regulatory proteins responsible for tumor invasion and metastases,
Inhibit VEGF, production and anti-VEGF1
Tactical’s CTO has comparable anti-tumoractivity to AVASTIN as monotherapy, but greater efficacy when each is given in combination with S-FU